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1

EGFR Antagonists in Cancer Treatment

Ciardiello, Fortunato, Tortora, Giampaolo

Journal:

Boston Medical and Surgical Journal

Year:

2008

Language:

english

File:

PDF, 461 KB

english, 2008

2

Gut microbiome, big data and machine learning to promote precision medicine for cancer

Cammarota, Giovanni, Ianiro, Gianluca, Ahern, Anna, Carbone, Carmine, Temko, Andriy, Claesson, Marcus J., Gasbarrini, Antonio, Tortora, Giampaolo

Journal:

Nature Reviews Gastroenterology and Hepatology (formerly Nature Clinical Practice Gastroenterology and Hepatology)

Year:

2020

File:

PDF, 1.56 MB

2020

3

Rational bases for the development of EGFR inhibitors for cancer treatment

Roberto Bianco, Teresa Gelardi, Vincenzo Damiano, Fortunato Ciardiello, Giampaolo Tortora

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2007

Language:

english

File:

PDF, 583 KB

english, 2007

4

Key cancer cell signal transduction pathways as therapeutic targets

Roberto Bianco, Davide Melisi, Fortunato Ciardiello, Giampaolo Tortora

Journal:

European Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 115 KB

english, 2006

5

Rationale and clinical use of multitargeting anticancer agents

Melisi, Davide, Piro, Geny, Tamburrino, Anna, Carbone, Carmine, Tortora, Giampaolo

Journal:

Current Opinion in Pharmacology

Year:

2013

Language:

english

File:

PDF, 790 KB

english, 2013

6

AR-V7 and prostate cancer: The watershed for treatment selection?

Ciccarese, Chiara, Santoni, Matteo, Brunelli, Matteo, Buti, Sebastiano, Modena, Alessandra, Nabissi, Massimo, Artibani, Walter, Martignoni, Guido, Montironi, Rodolfo, Tortora, Giampaolo, Massari, Fran

Journal:

Cancer Treatment Reviews

Year:

2016

Language:

english

File:

PDF, 940 KB

english, 2016

7

Prostate cancer heterogeneity: Discovering novel molecular targets for therapy

Ciccarese, Chiara, Massari, Francesco, Iacovelli, Roberto, Fiorentino, Michelangelo, Montironi, Rodolfo, Di Nunno, Vincenzo, Giunchi, Francesca, Brunelli, Matteo, Tortora, Giampaolo

Journal:

Cancer Treatment Reviews

Year:

2017

Language:

english

File:

PDF, 2.60 MB

english, 2017

8

Tp53 and its potential therapeutic role as a target in bladder cancer

Ciccarese, Chiara, Massari, Francesco, Blanca, Ana, Tortora, Giampaolo, Montironi, Rodolfo, Cheng, Liang, Scarpelli, Marina, Raspollini, Maria R, Vau, Nuno, Fonseca, Jorge, Lopez-Beltran, Antonio

Journal:

Expert Opinion on Therapeutic Targets

Year:

2017

Language:

english

File:

PDF, 1.50 MB

english, 2017

9

Exceptional Response to Cabozantinib of Rapidly Evolving Brain Metastases of Renal Cell Carcinoma: A Case Report and Review of the Literature

Ciccarese, Chiara, Iacovelli, Roberto, Mosillo, Claudia, Tortora, Giampaolo

Journal:

Clinical Genitourinary Cancer

Year:

2018

Language:

english

File:

PDF, 418 KB

english, 2018

10

Immune checkpoint inhibitors and prostate cancer: a new frontier?

Modena, Alessandra, Ciccarese, Chiara, Iacovelli, Roberto, Brunelli, Matteo, Montironi, Rodolfo, Fiorentino, Michelangelo, Tortora, Giampaolo, Massari, Francesco

Journal:

Oncology Reviews

Year:

2016

Language:

english

File:

PDF, 164 KB

english, 2016

11

PTEN in Lung Cancer: Dealing with the Problem, Building on New Knowledge and Turning the Game Around

Gkountakos, Anastasios, Sartori, Giulia, Falcone, Italia, Piro, Geny, Ciuffreda, Ludovica, Carbone, Carmine, Tortora, Giampaolo, Scarpa, Aldo, Bria, Emilio, Milella, Michele, Rosell, Rafael, Corbo, Vi

Journal:

Year:

2019

Language:

english

File:

PDF, 1.06 MB

english, 2019

12

PTEN in Colorectal Cancer: Shedding Light on Its Role as Predictor and Target

Salvatore, Lisa, Calegari, Maria Alessandra, Loupakis, Fotios, Fassan, Matteo, Di Stefano, Brunella, Bensi, Maria, Bria, Emilio, Tortora, Giampaolo

Journal:

Year:

2019

File:

PDF, 938 KB

2019

13

Differential immunohistochemical detection of transforming growth factor α, amphiregulin and CRIPTO in human normal and malignant breast tissues

Luigi Panico, Antonio D'Antonio, Gaetano Salvatore, Ernesto Mezza, Giampaolo Tortora, Michelino De Laurentiis, Sabino De Placido, Thomas Giordano, Maria Merino, David S. Salomon, William J. Gullick, G

Journal:

International Journal of Cancer

Year:

1996

Language:

english

File:

PDF, 782 KB

english, 1996

14

Transfection with a CRIPTO anti-sense plasmid suppresses endogenous CRIPTO expression and inhibits transformation in a human embryonal carcinoma cell line

Gustavo Baldassarre, Caterina Bianco, Giampaolo Tortora, Angela Ruggiero, Mark Moasser, Ethan Dmitrovsky, A. Raffaele Bianco, Fortunato Ciardiello

Journal:

International Journal of Cancer

Year:

1996

Language:

english

File:

PDF, 755 KB

english, 1996

15

Resistance to taxanes is induced by c-erbB-2 overexpression in human MCF-10A mammary epithelial cells and is blocked by combined treatment with an antisense oligonucleotide targeting type I protein kinase A

Fortunato Ciardiello, Rosa Caputo, Grazia Pomatico, Michelino De Laurentiis, Sabino De Placido, A. Raffaele Bianco, Giampaolo Tortora

Journal:

International Journal of Cancer

Year:

2000

Language:

english

File:

PDF, 122 KB

english, 2000

16

A novel MDM2 anti-sense oligonucleotide has anti-tumor activity and potentiates cytotoxic drugs acting by different mechanisms in human colon cancer

Giampaolo Tortora, Rosa Caputo, Vincenzo Damiano, Roberto Bianco, Jiangdong Chen, Sudhir Agrawal, A. Raffaele Bianco, Fortunato Ciardiello

Journal:

International Journal of Cancer

Year:

2000

Language:

english

File:

PDF, 150 KB

english, 2000

17

Clinical impact of anti-epidermal growth factor receptor monoclonal antibodies in first-line treatment of metastatic colorectal cancer : Meta-analytical estimation and implications for therapeutic strategies

Fotios Loupakis, Chiara Cremolini, Lisa Salvatore, Marta Schirripa, Sara Lonardi, Vanja Vaccaro, Federica Cuppone, Diana Giannarelli, Vittorina Zagonel, Francesco Cognetti, Giampaolo Tortora, Alfredo

Journal:

Year:

2012

Language:

english

File:

PDF, 1.41 MB

english, 2012

18

Flow-cytometric detection of the RIα subunit of type I cAMP-dependent protein kinase in human cells

Dr. Stefano Pepe, Angela Ruggiero, Giampaolo Tortora, Fortunato Ciardiello, Corrado Garbi, Hiroshi Yokozaki, Yoon S. Cho-Chung, Timothy Clair, Bjorn S. Skalhegg, Angelo R. Bianco

Journal:

Cytometry Part A

Year:

1994

Language:

english

File:

PDF, 680 KB

english, 1994

19

ZD1839 (IRESSA), an EGFR-selective tyrosine kinase inhibitor, enhances taxane activity in bcl-2 overexpressing, multidrug-resistant MCF-7 ADR human breast cancer cells

Fortunato Ciardiello, Rosa Caputo, Gaetano Borriello, Donatella Del Bufalo, Annamaria Biroccio, Gabriella Zupi, A. Raffaele Bianco, Giampaolo Tortora

Journal:

International Journal of Cancer

Year:

2002

Language:

english

File:

PDF, 339 KB

english, 2002

20

Antisense oligonucleotides targeting the epidermal growth factor receptor inhibit proliferation, induce apoptosis, and cooperate with cytotoxic drugs in human cancer cell lines

Fortunato Ciardiello, Rosa Caputo, Teresa Troiani, Gaetano Borriello, Ekambar R. Kandimalla, Sudhir Agrawal, John Mendelsohn, A. Raffaele Bianco, Giampaolo Tortora

Journal:

International Journal of Cancer

Year:

2001

Language:

english

File:

PDF, 210 KB

english, 2001

21

Carcinoembryonic antigen regulation in human colorectal tumor cells by a site-selective cyclic amp analogue: A comparison with interferon-gamma

Fiorella Guadagni, Giampaolo Tortora, Mario Roselli, Tim Clair, Yoon Sang Cho-Chung, Jeffrey Schlom, John W. Greiner

Journal:

International Journal of Cancer

Year:

1991

Language:

english

File:

PDF, 1.20 MB

english, 1991

22

Down-regulation of riα subunit of camp-dependent protein kinase induces growth inhibition of human mammary epithelial cells transformed by c-ha-ras and c-erbb-2 proto-oncogenes

Fortunato Ciardiello, Stefano Pepe, Caterina Bianco, Gustavo Baldassarre, Angela Ruggiero, Cataldo Bianco, Mouna P. Selvam, A. Raffaele Bianco, Giampaolo Tortora

Journal:

International Journal of Cancer

Year:

1993

Language:

english

File:

PDF, 716 KB

english, 1993

23

Infection with a transforming growth factor α anti-sense retroviral expression vector reduces the in vitro growth and transformation of a human colon cancer cell line

Fortunato Ciardiello, Catcrina Bianco, Nicola Normanno, Gustavo Baldassarre, Stefano Pepe, Giampaolo Tortora, A. Raffaele Bianco, David S. Salomon

Journal:

International Journal of Cancer

Year:

1993

Language:

english

File:

PDF, 819 KB

english, 1993

24

Differential effects of protein kinase a sub-units on chinese-hamster-ovary cell cycle and proliferation

Giampaolo Tortora, Stefano Pepe, Caterina Bianco, Vincenzo Damiano, Angela Ruggiero, Gustavo Baldassarre, Claudia Corbo, Yoon Sang Cho-Chung, A. Raffaele Bianco, Fortunato Ciardiello

Journal:

International Journal of Cancer

Year:

1994

Language:

english

File:

PDF, 601 KB

english, 1994

25

Amphiregulin anti-sense oligodeoxynucleotides inhibit growth and transformation of a human colon carcinoma cell line

Nicola Normanno, Mouna P. Selvam, Caterina Bianco, Vincenzo Damiano, Ernesto de Angelis, Michele Grassi, Gabriella Magliulo, Giampaolo Tortora, David S. Salomon, Fortunato Ciardiello

Journal:

International Journal of Cancer

Year:

1995

Language:

english

File:

PDF, 604 KB

english, 1995

26

Synergistic anti-proliferative and pro-apoptotic activity of combined therapy with bortezomib, a proteasome inhibitor, with anti-epidermal growth factor receptor (EGFR) drugs in human cancer cells

Tina Cascone, Maria Pia Morelli, Floriana Morgillo, Woo-Young Kim, Gabriella Rodolico, Stefano Pepe, Giampaolo Tortora, Liberato Berrino, Ho-Young Lee, John V. Heymach, Fortunato Ciardiello

Journal:

Journal of Cellular Physiology

Year:

2008

Language:

english

File:

PDF, 29 KB

english, 2008

27

The use of xenograft models for the selection of cancer treatments with the EGFR as an example

Teresa Troiani, Clorinda Schettino, Erika Martinelli, Floriana Morgillo, Giampaolo Tortora, Fortunato Ciardiello

Journal:

Critical Reviews in Oncology/Hematology

Year:

2008

Language:

english

File:

PDF, 187 KB

english, 2008

28

Mechanisms of resistance to EGFR inhibitors

Roberto Bianco, Teresa Gelardi, Vincenzo Damiano, Fortunato Ciardiello, Giampaolo Tortora

Journal:

Targeted Oncology

Year:

2007

Language:

english

File:

PDF, 142 KB

english, 2007

29

Primary and acquired resistance to anti-EGFR targeted drugs in cancer therapy

Floriana Morgillo, Maria Anna Bareschino, Roberto Bianco, Giampaolo Tortora, Fortunato Ciardiello

Journal:

Differentiation

Year:

2007

Language:

english

File:

PDF, 140 KB

english, 2007

30

Protein Kinase A as Target for Novel Integrated Strategies of Cancer Therapy

GIAMPAOLO TORTORA, FORTUNATO CIARDIELLO

Journal:

Annals of the New York Academy of Sciences

Year:

2002

Language:

english

File:

PDF, 238 KB

english, 2002

31

The RIα subunit of protein kinase A (PKA) binds to Grb2 and allows PKA interaction with the activated EGF-Receptor

Tortora, Giampaolo, Damiano, Vincenzo, Bianco, Caterina, Baldassarre, Gustavo, Bianco, A Raffaele, Lanfrancone, Luisa, Pelicci, Pier Giuseppe, Ciardiello, Fortunato

Journal:

Year:

1997

Language:

english

File:

PDF, 487 KB

english, 1997

32

Antisense Targeting Protein Kinase A Type I as a Drug for Integrated Strategies of Cancer Therapy

GIAMPAOLO TORTORA, FORTUNATO CIARDIELLO

Journal:

Annals of the New York Academy of Sciences

Year:

2003

File:

PDF, 166 KB

2003

33

Down-regulation of type I protein kinase A by transfection of human breast cancer cells with an epidermal growth factor receptor antisense expression vector

Fortunato Ciardiello, Mniralini Dixit, Giuditta di Isernia, Vincenzo Damiano, Roberto Bianco, A. Raffaele Bianco, Carlos L. Arteaga, Giampaolo Tortora

Journal:

Breast Cancer Research and Treatment

Year:

1998

Language:

english

File:

PDF, 166 KB

english, 1998

34

Weekly Docetaxel and Vinorelbine (VIN-DOX) as First Line Treatment in Patients with Hormone Refractory Prostate Cancer

Giuseppe Di Lorenzo, Carmine Pizza, Riccardo Autorino, Michele De Laurentiis, Ombretta Marano, Adele D’Alessio, Giuseppe Cancello, Vincenzo Altieri, Giampaolo Tortora, Sisto Perdonà, Angelo Raffaele B

Journal:

European Urology

Year:

2004

Language:

english

File:

PDF, 104 KB

english, 2004

35

Antisense strategies targeting protein kinase C: preclinical and clinical development

Giampaolo Tortora, Fortunato Ciardiello

Journal:

Seminars in Oncology

Year:

2003

Language:

english

File:

PDF, 82 KB

english, 2003

36

Adjuvant chemotherapy for resected non-small-cell lung cancer: future perspectives for clinical research

Maria Bonomi, Sara Pilotto, Michele Milella, Francesco Massari, Sara Cingarlini, Matteo Brunelli, Marco Chilosi, Giampaolo Tortora, Emilio Bria

Journal:

Journal of Experimental & Clinical Cancer Research

Year:

2011

Language:

english

File:

PDF, 196 KB

english, 2011

37

Expression of Wnt5a Is Downregulated by Extracellular Matrix and Mutated c-Ha-ras in the Human Mammary Epithelial Cell Line MCF-10A

Thuan D. Bui, Giampaolo Tortora, Fortunato Ciardiello, Adrian L. Harris

Journal:

Biochemical and Biophysical Research Communications

Year:

1997

Language:

english

File:

PDF, 1.29 MB

english, 1997

38

Cooperative effect of 8-Cl-cAMP and rhGM-CSF on the differentiation of HL-60 human leukemia cells

Giampaolo Tortora, Stefano Pepe, Hiroshi Yokozaki, Scott Meissner, Yoon S. Cho-Chung

Journal:

Biochemical and Biophysical Research Communications

Year:

1991

Language:

english

File:

PDF, 638 KB

english, 1991

39

Site-selective cyclic AMP analogs provide a new approach in the control of cancer cell growth

Dionyssios Katsaros, Giampaolo Tortora, Pierosandro Tagliaferri, Timothy Clair, Shamsia Ally, Leonard Neckers, Roland K. Robins, Yoon Sang Cho-Chung

Journal:

Year:

1987

Language:

english

File:

PDF, 448 KB

english, 1987

40

Site-selective 8-chloroadenosine 3′,5′-cyclic monophosphate inhibits transformation and transforming growth factor α production in Ki-ras-transformed rat fibroblasts

Giampaolo Tortora, Fortunato Ciardiello, Shamsia Ally, Timothy Clair, David S. Salomon, Yoon Sang Cho-Chung

Journal:

Year:

1989

Language:

english

File:

PDF, 477 KB

english, 1989

41

Site-selective 8-C1-cAMP which causes growth inhibition and differentiation increases DNA (CRE)-binding activity in cancer cells

Maija I. Mednieks, Hiroshi Yokozaki, Giorgio R. Merlo, Giampaolo Tortora, Timothy Clair, Shamsia Ally, Eiichi Tahara, Yoon Sang Cho-Chung

Journal:

Year:

1989

Language:

english

File:

PDF, 905 KB

english, 1989

42

Overcoming resistance to molecularly targeted anticancer therapies: Rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies

Giampaolo Tortora, Roberto Bianco, Gennaro Daniele, Fortunato Ciardiello, James A. McCubrey, Maria Rosaria Ricciardi, Ludovica Ciuffreda, Francesco Cognetti, Agostino Tafuri, Michele Milella

Journal:

Drug Resistance Updates

Year:

2007

Language:

english

File:

PDF, 849 KB

english, 2007

43

Development of novel cancer chemopreventive agents in Europe – Neglected Cinderella or rising phoenix?: A critical commentary. ESF Workshop on Cancer Chemoprevention, DKFZ, Heidelberg, September 18–20, 2005

Clarissa Gerhauser, Helmut Bartsch, James Crowell, Silvio De Flora, Maurizio D’Incalci, Christian Dittrich, Norbert Frank, Enrico Mihich, Christian Steffen, Giampaolo Tortora, Andreas Gescher

Journal:

European Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 143 KB

english, 2006

44

Epidermal growth factor receptor (EGFR) as a target in cancer therapy: understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs

F. Ciardiello, Giampaolo Tortora

Journal:

European Journal of Cancer

Year:

2003

Language:

english

File:

PDF, 249 KB

english, 2003

45

Suppression of malignancy targeting the intracellular signal transducing proteins of cAMP: The use of site-selective cAMP analogs, antisense strategy, and gene transfer

Yoon S. Cho-Chung, Timothy Clair, Giampaolo Tortora, Hiroshi Yokozaki, Stefano Pepe

Journal:

Year:

1991

Language:

english

File:

PDF, 771 KB

english, 1991

46

Role of site-selective cAMP analogs in the control and reversal of malignancy

Yoon S. Cho-Chung, Timothy Clair, Giampaolo Tortora, Hiroshi Yokozaki

Journal:

Pharmacology & Therapeutics

Year:

1991

Language:

english

File:

PDF, 4.20 MB

english, 1991

47

The role of bevacizumab in breast cancer

Gennaro Daniele, Roberta Marciano, Giampaolo Tortora

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 106 KB

english, 2008

48

Reduction of RIα Subunit of cAMP-dependent Protein Kinase Expression Induces Growth Inhibition of Human Mammary Epithelial Cells Transformed by TGF-α, c-Ha-ras, and c-erbB-2 Genes

FORTUNATO CIARDIELLO, GIAMPAOLO TORTORA, STEFANO PEPE, CATERINA BIANCO, GUSTAVO BALDASSARRE, ANGELA RUGGIERO, CATALDO BIANCO, MOUNA P. SELVAM, A. RAFFAELE BIANCO

Journal:

Annals of the New York Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 354 KB

english, 1993

49

Involvement of Growth Factor Receptors of the Epidermal Growth Factor Receptor Family in Prostate Cancer Development and Progression to Androgen Independence

Di Lorenzo, Giuseppe, Bianco, Roberto, Tortora, Giampaolo, Ciardiello, Fortunato

Journal:

Clinical Prostate Cancer

Year:

2003

Language:

english

File:

PDF, 592 KB

english, 2003

50

Increased anaerobic metabolism is a distinctive signature in a colorectal cancer cellular model of resistance to antiepidermal growth factor receptor antibody

Monteleone, Francesca, Rosa, Roberta, Vitale, Monica, D'Ambrosio, Chiara, Succoio, Mariangela, Formisano, Luigi, Nappi, Lucia, Romano, Maria Fiammetta, Scaloni, Andrea, Tortora, Giampaolo, Bianco, Rob

Journal:

Year:

2013

Language:

english

File:

PDF, 837 KB

english, 2013

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